The museum, inaugurated in 1967 as the National Archaeological Museum, houses artifacts from the ancient civilizations of central and southern Sicily, from prehistory to the early Middle Ages.

The introduction to the entire museum itinerary through literary sources on history and topography

Greek statuary

The necropolises in the area: funeral rites and customs, sarcophagi, and grave goods

The Agrigento area before the Greeks: from prehistory to protohistory; the sites of Palma di Montechiaro, Piano Vento, and the sanctuary of Monte Grande.

The western part of Agrigento: S. Angelo Muxaro (Camico), Ribera and its necropolises; the cult caves of Monte Kronio and the Eneolithic grave goods of Tranchina.

The Hellenization of Agrigento: Eraclea Minoa, outpost of Akragas; Mount Adranone between the Sicani and Elymian-Punic peoples; the Roman baths of Vito Soldano.

Gela, homeland of Akrágas: its foundation and expansion; an artifact and images of the treasures kept in the city museum.

Province of Enna: Montagna di Marzo (Erbesso), Hellenized center. Focus on Tomb 31: warriors, helmets, and a rare vase with Italic inscription.